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Updated: Jul 10, 2025

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
[Function of innate lymphoid cells in the antifungal immune response]
Xiaofan Yin1, Han Wu1, Weilin Chen2
1Shenzhen University Health Science Center, Shenzhen University, Shenzhen 518060, China.
Abstract:
Invasive fungal diseases are increasing in incidence and mortality. A variety of immune cells are required to fight against fungal infections. The four subpopulations of innate lymphoid cells (ILCs), namely natural killer cell (NK cell), ILC1, ILC2 and ILC3, have different roles in the immune response to fungal infection. NK cells and ILC3 play the main role in killing fungi and protecting the host, while ILC2 itself does not have significant resistance to fungal infection, but because of its cell plasticity, inflammatory ILC2 can be transformed into ILC3 under certain conditions. The main function of ILCs is to produce cytokines which either directly kill fungi or indirectly regulate the immune response, promoting the body to complete the antifungal immune process.
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