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Detailed high quality surface-based mouse CAD model suitable for electromagnetic simulations.

Peter Serano1,2, Sergey Makaroff1,3, Jerome L Ackerman3

  • 1ECE, Worcester Polytech. Inst., 100 Institute Rd. Worcester MA 01609-2280, United States of America.

Biomedical Physics & Engineering Express
|November 20, 2023
PubMed
Summary

A new computational surface-based mouse model aids transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) research. This accurate CAD model supports electromagnetic modeling for understanding brain activity and connectivity in rodents.

Keywords:
MRITMSanimal CAD modelselectromagnetic modelingfMRImouse brain connectomes

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Computational Biology

Background:

  • Transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) are vital tools for studying brain function in small animals.
  • Accurate computational models are needed to support TMS and fMRI research, particularly for electromagnetic modeling across various frequencies.

Purpose of the Study:

  • To develop and demonstrate the utility of an accurate, surface-based computational CAD model of a mouse.
  • To optimize the model for computational electromagnetic modeling in both low- and high-frequency ranges.
  • To support advanced research in rodent brain connectivity and functionality.

Main Methods:

  • Development of a computational CAD model based on the Digimouse labeled atlas data.
  • Inclusion of a detailed four-compartment brain representation (whole brain, external cerebrum, cerebellum, striatum) with 21 distinct compartments.
  • Validation through four distinct low- and high-frequency modeling examples.

Main Results:

  • An accurate, multi-compartment computational CAD model of a mouse was successfully developed.
  • The model demonstrates applicability for electromagnetic modeling across a wide frequency spectrum.
  • Demonstrated utility in supporting TMS and fMRI research paradigms.

Conclusions:

  • The developed mouse CAD model is a valuable tool for computational electromagnetic modeling in neuroscience research.
  • This model can enhance the accuracy and scope of TMS and fMRI studies in rodents.
  • Facilitates further investigation into brain activation, connectivity, and functional mechanisms in small animal models.