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Multiple joint osteoarthritis (MJOA): What's in a name?
1Department of Medicine, Division of Rheumatology, Allergy, and Immunology, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Osteoarthritis and Cartilage
|November 20, 2023
Summary
Multi-joint osteoarthritis (MJOA) lacks a clear definition but commonly affects individuals. A higher burden of MJOA negatively impacts health outcomes, necessitating further research into its unique factors.
Area of Science:
- Rheumatology
- Epidemiology
- Genetics
Background:
- Osteoarthritis (OA) commonly affects multiple joints, a condition termed multi-joint osteoarthritis (MJOA).
- Current literature presents challenges due to variable definitions and a lack of consensus on MJOA.
- Understanding MJOA is crucial for comprehending the full spectrum of OA.
Purpose of the Study:
- To review the current literature on multi-joint osteoarthritis (MJOA).
- To discuss future research directions for MJOA.
Main Methods:
- A narrative review approach was employed.
- Key references and the Johnston County studies were analyzed.
- Focus areas included MJOA definitions, multi-site pain, genetics, and biomarkers.
Main Results:
- MJOA lacks a standardized definition, complicating research.
- The prevalence and patterns of MJOA vary across demographic groups.
- Increased whole-body OA burden significantly worsens health, function, and mortality.
Conclusions:
- Consistent MJOA definitions are essential for accurate phenotyping and epidemiological studies.
- Investigating unique genetic and biomarker profiles in MJOA is critical.
- Addressing MJOA is vital for mitigating the overall health impact of osteoarthritis.
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