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Paving the way for new and challenging matrix reference materials-particle suspensions at the core of material

Håkan Emteborg1, John Seghers2, Silvia García-Ruiz2

  • 1European Commission, Joint Research Centre (JRC), Geel, Belgium. hakan.emteborg@ec.europa.eu.

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Producing homogeneous matrix reference materials (RMs) is crucial for reliable analytical results. This study details a particle suspension method to create challenging RMs, achieving low heterogeneity for various environmental samples.

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Environmental Science

Background:

  • Homogeneity of certified parameters is a critical quality indicator for matrix reference materials (RMs).
  • Heterogeneity assessment quantifies parameter variation within an RM batch, with lower values indicating higher quality.
  • Challenging matrices like environmental samples are difficult to homogenize due to handling and dosing limitations.

Purpose of the Study:

  • To report on the production of challenging matrix reference materials (RMs) using particle suspension techniques.
  • To demonstrate the effectiveness of this method for various complex matrices, including water, atmospheric dust, and microplastics.
  • To address the RM/Method causality dilemma in emerging fields by proposing collaborative strategies.

Main Methods:

  • Utilized particle suspensions as the core processing step for material production.
  • Employed continuously stirred suspensions during material processing for difficult-to-handle matrices.
  • Evaluated heterogeneity by calculating relative between-bottle variations for target parameters.

Main Results:

  • Successfully produced challenging matrix RMs for persistent organic pollutants in water, ions in PM2.5-like dust, and microplastics.
  • Achieved general relative between-bottle heterogeneities ranging from 1.6% to 6% for target parameters.
  • Demonstrated the applicability of the particle suspension method across diverse and complex sample types.

Conclusions:

  • Particle suspension is an effective method for producing homogeneous challenging matrix reference materials.
  • Collaboration between RM producers and analytical method developers is essential to overcome the RM/Method causality dilemma.
  • Development of well-homogenized common samples can accelerate advancements in analytical method development and RM production.