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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

134
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
134

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Related Experiment Video

Updated: Jul 10, 2025

Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution
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Sticking Detection by Repeated Compactions on a Single Tablet.

James Thomas1,2, Phuong Bui2, Antonios Zavaliangos3

  • 1Drug Substance Development - Material Science, GlaxoSmithKline, 1250 S, Collegeville Rd, Collegeville, PA, 19426, United States of America.

AAPS Pharmscitech
|November 22, 2023
PubMed
Summary
This summary is machine-generated.

Detecting tablet sticking early is crucial for pharmaceutical manufacturing. A new single tablet multi-compaction (STMC) method uses a laser sensor to assess sticking propensity with minimal material, aiding early R&D.

Keywords:
STMCadhesionlaser sensorstickingtablet

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Area of Science:

  • Pharmaceutical Manufacturing
  • Materials Science
  • Process Engineering

Background:

  • Tablet sticking, the adherence of material to punches, compromises tablet quality and halts production.
  • Early detection of sticking risk is vital in R&D to mitigate delays and costs.
  • Limited material availability in early drug development poses challenges for traditional sticking assessment.

Purpose of the Study:

  • To introduce and validate a material-sparing method for assessing tablet sticking propensity.
  • To evaluate the efficacy of single tablet multi-compaction (STMC) combined with laser sensing for early-stage R&D.

Main Methods:

  • Utilized single tablet multi-compaction (STMC) to repeatedly compact a single tablet.
  • Employed a highly sensitive laser reflection sensor to detect material accumulation on the punch.
  • Tested ibuprofen powder blends to assess sticking propensity across different formulations and punch speeds.

Main Results:

  • STMC successfully differentiated sticking tendencies among various powder formulations.
  • The method replicated sticking trends observed at different punch speeds.
  • The laser sensor provided sensitive detection of adhered material.

Conclusions:

  • STMC is a highly material-sparing methodology suitable for early-stage pharmaceutical development.
  • This technique enables early assessment of tablet sticking propensity, facilitating timely mitigation strategies.
  • The combination of STMC and laser sensing offers a robust solution for predicting and managing tablet sticking.