Rationale and design of the ESC Heart Failure III Registry - Implementation and discovery

Area of Science:

• Cardiology
• Clinical Research
• Public Health

Background:

• Heart failure (HF) outcomes remain suboptimal despite therapeutic advancements.
• The European Society of Cardiology Heart Failure III Registry (ESC HF III Registry) was established to address this gap.
• Characterizing contemporary HF patient populations and treatment patterns is crucial.

Purpose of the Study:

• To characterize clinical features and outcomes of heart failure (HF) patients.
• To assess the implementation of guideline-recommended therapies in Europe and affiliated countries.
• To provide data for improving HF management strategies.

Main Methods:

• Prospective, observational registry including 10,162 patients with chronic or acute/worsening HF.
• Data collected from November 2018 to December 2020 across 220 centers in 41 countries.
• Comprehensive data collection on demographics, medical history, diagnostics, treatments, and 12-month outcomes.

Main Results:

• Detailed characterization of a large, contemporary European HF cohort.
• Assessment of guideline-directed medical therapy (GDMT) use and adherence.
• Analysis of HF patient outcomes, including cause-specific mortality and hospitalizations.

Conclusions:

• The ESC HF III Registry offers unique insights into current HF management and patient outcomes.
• Findings may inform the development of improved implementation strategies for HF therapies.
• The registry data can impact clinical discovery, clinical trial design, and health policy decisions.