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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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FATIGUE IN PATIENTS WITH LONG COVID.

K Ivantsov1, V Lim1, I Kukes2

  • 11I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia.

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Summary

Long COVID fatigue involves abnormal metabolic profiles, including elevated lactate and dimethylarginine levels. Moderate physical activity improved fatigue symptoms and clinical outcomes in patients.

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Area of Science:

  • Metabolomics
  • Long COVID research
  • Post-viral syndromes

Background:

  • Long COVID, a condition following SARS-CoV-2 infection, frequently presents with persistent fatigue.
  • Understanding the underlying pathophysiology of Long COVID fatigue is crucial for developing effective treatments.

Purpose of the Study:

  • To characterize the metabolomic profile in patients experiencing fatigue associated with Long COVID.
  • To observe dynamic changes in metabolic parameters during a period of physical activity intervention.

Main Methods:

  • Prospective study of 24 patients diagnosed with "Condition after COVID-19 unspecified" (U09.9).
  • Clinical assessments included the Modified Medical Research Council (MRC) dyspnea scale, 6-minute walk test (6MWT), Multidimensional Fatigue Inventory (MFI) scale, and Barthel Index.
  • Metabolomic parameters were determined at baseline and during follow-up (days 1 and 14-18).
  • Patients engaged in moderate aerobic activity (walking 45 minutes, 3 times/week).

Main Results:

  • Elevated levels of lactate, fumaric acid, symmetrical dimethylarginine (SDMA), and asymmetrical dimethylarginine (ADMA) were observed.
  • Adipic acid levels normalized during the study period.
  • Significant improvements (p<0.001) were noted in MRC, MFI, 6MWT, and Barthel Index scores following physical activity.
  • The metabolic profile at 60 days post-onset indicated complex abnormalities.

Conclusions:

  • The metabolic profile of Long COVID patients exhibits a complex set of abnormalities.
  • These metabolic alterations suggest potential therapeutic targets for pathogenetic pharmacotherapy.
  • Physical activity interventions show promise in improving both clinical symptoms and functional outcomes in Long COVID fatigue.