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Updated: Jul 10, 2025
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Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
Published on: September 5, 2016
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Gene therapy to cure HIV infection.
Ryan P Goguen1, Michelle J Chen2, Owen R S Dunkley2
1Lady Davis Institute for Medical Research, Montréal, Québec, H3T 1E2, Canada, Department of Microbiology and Immunology, McGill University, Montréal, Québec, H3A 0G4, Canada.
Virologie (Montrouge, France)
|November 24, 2023
Summary
Bone marrow transplants can cure HIV, but are risky. Gene therapy offers a safer alternative by engineering a patient's own cells to resist HIV, paving the way for a potential cure.
Area of Science:
- Immunology
- Molecular Biology
- Gene Therapy
Background:
- Bone marrow transplants from HIV-resistant donors have cured HIV infection but carry high mortality risks.
- Current limitations necessitate alternative strategies for HIV cure.
- Gene therapy presents a promising avenue for developing safer HIV treatments.
Conclusions:
- Gene therapy offers a safer alternative to bone marrow transplants for HIV cure.
- Combining different gene therapy modalities may lead to a safe and effective HIV cure.
- Further research is needed to optimize combination gene therapy for widespread clinical application.
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