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Short-Stranded Zein Fibers for Muscle Tissue Engineering in Alginate-Based Composite Hydrogels.

Lea Melzener1,2, Sergio Spaans2, Nicolas Hauck2

  • 1Department of Physiology, Maastricht University, 6200 MD Maastricht, The Netherlands.

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Summary
This summary is machine-generated.

Adding zein fibers to alginate hydrogels improves cultivated meat production. This fiber-hydrogel composite enhances cell alignment and maturation, leading to better muscle development for a more sustainable meat alternative.

Keywords:
alginate hydrogelcultivated meatcultured meatelectrospinningfiber-hydrogel compositesmuscle tissuetissue engineeringzein

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Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Food Technology

Background:

  • Cultivated meat offers an ethical and sustainable alternative to conventional meat.
  • Producing mature skeletal muscle is crucial for the quality of cultivated meat.
  • Alginate hydrogels are promising for muscle tissue engineering but have mechanical limitations.

Purpose of the Study:

  • To enhance the myogenic differentiation and maturation of bovine muscle precursor cells in alginate-based hydrogels.
  • To overcome the mechanical limitations of alginate hydrogels for improved cell development.
  • To investigate the effect of incorporating electrospun zein fibers into alginate hydrogels.

Main Methods:

  • Fabrication of alginate hydrogels functionalized with electrospun short-stranded zein fibers.
  • Culturing bovine muscle precursor cells within the fiber-hydrogel composites.
  • Analysis of cell alignment, myogenic differentiation, maturation, and hydrogel properties.

Main Results:

  • Zein fibers increased hydrogel degradation, leading to faster compaction and improved cell-gel interactions.
  • Enhanced alignment and myogenic differentiation of bovine muscle precursor cells were observed.
  • The fiber-hydrogel composite improved tissue stability, enabling prolonged culture duration and enhanced muscle organoid maturation.

Conclusions:

  • Fiber-hydrogel composites represent a promising strategy for optimizing 3D cultivated meat production.
  • Incorporating zein fibers overcomes alginate's mechanical limitations, facilitating better cell development and tissue maturation.
  • This approach improves muscle-related protein content and primes muscle organoids for advanced maturation.