Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 10, 2025

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
12:18

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft

Published on: August 8, 2020

10.1K

Graft-Host Interaction and Its Effect on Wound Repair Using Mouse Models.

Nicole Garcia1,2, Md Mostafizur Rahman1,2, Carlos Luis Arellano1,2

  • 1Skin Bioengineering Laboratory, Victorian Adult Burns Service, Alfred Health, 89 Commercial Road, Melbourne, VIC 3004, Australia.

International Journal of Molecular Sciences
|November 25, 2023
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimising Patient Safety During the Use of Intraoperative Imaging for the Surgical Management of Facial Fractures: A Pilot Study.

Craniomaxillofacial trauma & reconstruction·2026
Same author

Developing Provider-Co-Created Prototypes Addressing Equity-Related Barriers in Liver Transplantation for Hepatocellular Carcinoma.

medRxiv : the preprint server for health sciences·2026
Same author

The Efficacy of UV-C Disinfection in Decreasing Hospital-Acquired Infections and Bioburden in an Adult Burns Service.

European burn journal·2026
Same author

Platelet-Targeted Self-Amplifying mRNA for Safe, Long-Acting Thromboprophylaxis.

Circulation research·2026
Same author

Harnessing Immune Pathways for Stroke Recovery: Overcoming Challenges to Clinical Translation.

Circulation research·2026
Same author

A novel engineered skin closes full thickness burn wounds: A case report.

JPRAS open·2026
Same journal

RETRACTED: Kim et al. The Angiogenesis Inhibitor ALS-L1023 from Lemon-Balm Leaves Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease Through Regulating the Visceral Adipose-Tissue Function. <i>Int. J. Mol. Sci.</i> 2017, <i>18</i>, 846.

International journal of molecular sciences·2026
Same journal

Correction: Mahmud et al. Thymoquinone Attenuates NF-κβ Signalling Activation in Retinal Pigment Epithelium Cells Under AMD-Mimicking Conditions. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 11473.

International journal of molecular sciences·2026
Same journal

Correction: Borovikov et al. The Twisting and Untwisting of Actin and Tropomyosin Filaments Are Involved in the Molecular Mechanisms of Muscle Contraction, and Their Disruption Can Result in Muscle Disorders. <i>Int. J. Mol. Sci</i>. 2025, <i>26</i>, 6705.

International journal of molecular sciences·2026
Same journal

Correction: Molagoda et al. Flavonoid Glycosides from <i>Ziziphus jujuba</i> var. <i>inermis</i> (Bunge) Rehder Seeds Inhibit α-Melanocyte-Stimulating Hormone-Mediated Melanogenesis. <i>Int. J. Mol. Sci.</i> 2021, <i>22</i>, 7701.

International journal of molecular sciences·2026
Same journal

Correction: Guo et al. Integrated Transcriptomic and Metabolomic Analysis Reveals the Molecular Regulatory Mechanism of Flavonoid Biosynthesis in Maize Roots Under Lead Stress. <i>Int. J. Mol. Sci.</i> 2024, <i>25</i>, 6050.

International journal of molecular sciences·2026
Same journal

Correction: Chang et al. Improvement of Carbon Tetrachloride-Induced Acute Hepatic Failure by Transplantation of Induced Pluripotent Stem Cells Without Reprogramming Factor c-Myc. <i>Int. J. Mol. Sci.</i> 2012, <i>13</i>, 3598-3617.

International journal of molecular sciences·2026
See all related articles
This summary is machine-generated.

Autologous skin grafting reduces inflammatory markers and wound contraction compared to synthetic grafts. This study clarifies molecular differences in wound repair for better engineered skin graft design.

Area of Science:

  • Regenerative Medicine
  • Wound Healing Research
  • Biomaterials Science

Background:

  • Autologous skin grafting is a standard wound closure technique, but underlying molecular mechanisms remain unclear.
  • Understanding cellular and molecular interactions is crucial for developing advanced wound repair strategies.
  • Engineered skin grafts require a molecular basis for design and testing.

Purpose of the Study:

  • To elucidate molecular changes in wound beds following autologous and synthetic skin grafting.
  • To compare the inflammatory and reparative responses to different graft types.
  • To establish a foundation for designing novel engineered skin substitutes.

Main Methods:

  • Utilized a full-thickness skin graft mouse model (SKH-1 hairless).
Keywords:
IL-6TGF-β1myofibroblastskin graftingwound repair

More Related Videos

Murine Model of Wound Healing
05:39

Murine Model of Wound Healing

Published on: May 28, 2013

64.4K
Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

8.7K

Related Experiment Videos

Last Updated: Jul 10, 2025

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
12:18

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft

Published on: August 8, 2020

10.1K
Murine Model of Wound Healing
05:39

Murine Model of Wound Healing

Published on: May 28, 2013

64.4K
Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

8.7K
  • Applied either autologous full-thickness skin grafts (FTSG) or synthetic Biodegradable Temporising Matrix (BTM).
  • Performed histological, RNA, and protein analyses at key wound repair phases (days 1, 5, 21).

    • Main Results:

    • Autologous FTSG significantly reduced inflammatory markers (Il-6, Cxcl-1, Cxcl-5/6) compared to controls.
    • Synthetic BTM grafts showed persistently high levels of Cxcl-1 and Cxcl-5/6 up to 21 days.
    • Autologous FTSG decreased wound contraction, while synthetic grafts exhibited greater contraction, potentially due to myofibroblasts and TGF-β1.
    • No TGF-β1-mediated Connective Tissue Growth Factor (CTGF) upregulation was observed.

    Conclusions:

    • Autologous skin grafting modulates the wound environment by reducing inflammation and contraction.
    • Synthetic grafts elicit a prolonged inflammatory response and increased contraction.
    • Findings provide molecular insights for optimizing engineered skin graft development.