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Rapid Radiolabeling for Peptide Radiotracers
Xiaowei Ma1, Zhen Cheng2,3
1Department of Nuclear Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Methods in Molecular Biology (Clifton, N.J.)
|November 25, 2023
Summary
Peptide-based radiopharmaceuticals (PRPs) enable advanced diagnostic imaging and therapy. This chapter details six rapid radiolabeling methods for preparing PRPs using metallic radioisotopes and Fluorine-18.
Area of Science:
- Nuclear medicine
- Radiopharmaceutical chemistry
Background:
- Peptide-based radiopharmaceuticals (PRPs) have been utilized for over 20 years in diagnostic imaging and targeted radionuclide therapy.
- Efficient preparation of PRPs is crucial for their clinical application.
Purpose of the Study:
- To present common and rapid radiolabeling methods for peptide-based radiopharmaceuticals.
- To cover radiolabeling techniques using metallic radioisotopes and Fluorine-18.
Main Methods:
- Review of six established radiolabeling approaches for PRPs.
- Focus on methods suitable for metallic radioisotopes (e.g., 99mTc, 68Ga, 111In).
- Inclusion of methods for the positron-emitting isotope Fluorine-18 (18F).
Main Results:
- Six distinct radiolabeling strategies for PRPs are described.
- Methods facilitate rapid incorporation of radioisotopes, crucial for short-lived isotopes.
- Techniques are applicable to both diagnostic and therapeutic radioisotopes.
Conclusions:
- Rapid radiolabeling is essential for the effective use of PRPs in nuclear medicine.
- The presented methods offer a practical guide for PRP preparation.
- These techniques support the advancement of PRP-based diagnostics and therapeutics.
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