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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Jul 10, 2025

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

Published on: May 30, 2011

Arterial Spin Labeling Perfusion Imaging.

Manuel Taso¹, David C Alsop¹

¹Division of MRI Research, Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

Magnetic Resonance Imaging Clinics of North America

|November 25, 2023

Summary

This summary is machine-generated.

Arterial spin labeling (ASL) offers noninvasive MRI to measure tissue perfusion and blood flow. This technique, using labeled arterial blood as a tracer, is vital for studying brain function and various neurological conditions.

Keywords:

Arterial spin labeling Blood flow MR imaging Perfusion

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Area of Science:

Medical Imaging
Neuroscience
Biophysics

Background:

Noninvasive imaging of tissue perfusion is crucial for research and clinical settings.
Arterial spin labeling (ASL) is a key MRI technique for assessing blood flow without contrast agents.

Purpose of the Study:

To review the fundamental principles of ASL perfusion imaging.
To discuss ASL labeling strategies and quantification methods.
To highlight the broad applications of ASL in neuroscience and clinical pathology.

Main Methods:

ASL utilizes radiofrequency and magnetic field gradients to label arterial blood water.
Labeled arterial blood acts as an endogenous tracer for perfusion measurement.
Quantitative analysis of tissue blood flow is achieved through ASL techniques.

Main Results:

ASL provides a contrast-free method for imaging tissue perfusion.
The technique allows for precise measurement and quantification of blood flow.
ASL has demonstrated significant utility over three decades of research.

Conclusions:

ASL is a versatile and established tool for noninvasive perfusion imaging.
Its applications span normal brain function, neurovascular diseases, neuro-oncology, and degenerative conditions.
Continued advancements in ASL contribute significantly to medical research and patient care.