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Updated: Jul 10, 2025
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
IL-6 Enhances the Viability and Invasion Ability of Prostate Cancer Cells
Kai Cheng1,2, Christopher Batbatan2, Qingmei Jia3
1Department of Biology, College of Arts and Sciences, Central Mindanao University, Musuan, Bukidnon 8714, Philippines.
Abstract:
Prostate cancer is a slow-growing cancer whose incidence increases with age. IL-6 expression is significantly increased in a variety of malignant tumor stroma, which is a key factor involved in the association between inflammation and tumor. So as to investigate how prostate cancer works, recombinant IL-6 was used to stimulate human prostate cancer cells (PC-3). After treatment for 24,48,72h, the viability of cancer cells was detected by CCK-8 experiment. The effect of recombinant IL-6 on the invasion of prostate cancer cells was analyzed by Transwell experiment. The results showed that IL-6 can increase the viability of prostate cancer cells and facilitate the invasion of prostate cancer cells.
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