Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-seq.

Nature biotechnology·2026
Same author

Lysosome-Targeting Chimeras (LYTACs): From Modular Design Principles to Diverse Therapeutic Applications.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

SpatioCell: deep integration of histology and spatial transcriptomics for profiling the cellular microenvironment at single-cell level.

Science bulletin·2026
Same author

Cyclic transformation of stable/metastable nucleic acid structures enables dynamic monitoring of ATP in living cells.

Chemical science·2026
Same author

Dual-Spatially Confined Assembly of DNA Nanowall Stiffens Tumor Cells to Enhance Adoptive T-Cell Immunotherapy.

Journal of the American Chemical Society·2026
Same author

Tracing Tumor-Derived Extracellular Vesicle Matrix Metalloproteinase 14 Using Dual-Target Orthogonal Barcoding-Based Microscale Thermophoretic Assays.

ACS nano·2026
Same journal

Analyses of dextroamphetamine and its metabolites in human urine by capillary electrophoresis with diode array and capacitively coupled contactless conductivity detection (CE-DAD-C<sup>4</sup>D).

Analytical and bioanalytical chemistry·2026
Same journal

Whole-body mass spectrometry imaging reveals metabolome and lipid peroxidation heterogeneity in zebrafish xenografts of esophageal squamous cell carcinoma.

Analytical and bioanalytical chemistry·2026
Same journal

A robust and validated method for the determination of 21 urinary metabolites of 15 plasticizers, including phthalates, DEHTP, and DINCH, by online SPE and liquid chromatography-tandem mass spectrometry.

Analytical and bioanalytical chemistry·2026
Same journal

A label-free membrane-based biosensor array with AuNP-modified PDMS for sensitive and specific detection of alpha-fetoprotein.

Analytical and bioanalytical chemistry·2026
Same journal

Smartphone-integrated one-step colorimetric glucose detection at physiological pH enabled by a haloperoxidase mimic.

Analytical and bioanalytical chemistry·2026
Same journal

Chemiluminescence functionalized magnetic nanoparticles-based biosensor for sensitive detection of glucose, uric acid, and cholesterol.

Analytical and bioanalytical chemistry·2026
See all related articles

Related Experiment Video

Updated: Jul 10, 2025

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

14.9K

Beyond single cells: microfluidics empowering multiomics analysis.

Tian Tian1, Shichao Lin2, Chaoyong Yang3,4

  • 1Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.

Analytical and Bioanalytical Chemistry
|November 26, 2023
PubMed
Summary
This summary is machine-generated.

Single-cell multiomics, using microfluidic technology, enables simultaneous molecular measurements for deeper biological insights. This review highlights advanced platforms and future applications in genomics, transcriptomics, epigenomics, and proteomics.

Keywords:
MicrofluidicsMultiomicsSingle-cellscRNA-seq

More Related Videos

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing
10:00

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

Published on: May 23, 2018

17.7K
Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses
09:43

Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses

Published on: March 8, 2024

1.7K

Related Experiment Videos

Last Updated: Jul 10, 2025

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

14.9K
An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing
10:00

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

Published on: May 23, 2018

17.7K
Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses
09:43

Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses

Published on: March 8, 2024

1.7K

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Genomics

Background:

  • Single-cell multiomics allows simultaneous measurement of diverse molecules within individual cells, surpassing traditional single-layer analyses.
  • Microfluidic technology is crucial for high-throughput single-cell analysis, providing precise cell control and manipulation.

Purpose of the Study:

  • To review cutting-edge microfluidic platforms for single-cell multiomics.
  • To discuss advancements in single-cell genomics, transcriptomics, epigenomics, and proteomics.
  • To explore future prospects of integrated single-cell multiomics methodologies.

Main Methods:

  • Review of current literature on microfluidic platforms for single-cell multiomics.
  • Analysis of technological progress in genomics, transcriptomics, epigenomics, and proteomics.
  • Discussion of integrated multiomics approaches.

Main Results:

  • Identification of key microfluidic platforms enabling single-cell multiomics.
  • Overview of technological innovations across various single-cell omics fields.
  • Highlighting the synergistic potential of combining different omics data at the single-cell level.

Conclusions:

  • Integrated single-cell multiomics platforms driven by microfluidics offer unprecedented biological insights.
  • Continued technological development promises expanded applications in fundamental and applied biological research.
  • The future of biological research lies in leveraging these advanced multiomics approaches for comprehensive cellular understanding.