Related Experiment Video
Updated: Jul 9, 2025
09:35
Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
Published on: May 10, 2017
18.9K
Altered brain function in classical trigeminal neuralgia patients: ALFF, ReHo, and DC static- and dynamic-frequency
Xiuhong Ge1,2, Luoyu Wang1,2, Juncheng Yan3
1Department of Radiology, Hangzhou First People's Hospital, No. 261, Huansha Road, Shangcheng District, Hangzhou City, Zhejiang Province 310000, China.
Cerebral Cortex (New York, N.Y. : 1991)
|November 27, 2023
Summary
This study reveals altered brain function in classical trigeminal neuralgia (CTN) patients, particularly in the classical and slow-4 frequency bands. These changes in brain regions correlate with clinical symptoms and mental health.
Area of Science:
- Neuroscience
- Medical Imaging
- Neurology
Background:
- Classical trigeminal neuralgia (CTN) significantly impacts patient mental health.
- Understanding the neurobiological underpinnings of CTN is crucial for effective treatment.
Purpose of the Study:
- To clarify brain function alterations in classical trigeminal neuralgia (CTN) patients.
- To investigate brain activity across static and dynamic low-frequency fluctuation bands.
- To identify specific brain regions and frequency bands affected in CTN.
Main Methods:
- Analysis of 77 CTN patients and 73 healthy controls (HCs).
- Utilized static and dynamic amplitude of low-frequency fluctuation (sALFF, dALFF), regional homogeneity (sReHo, dReHo), and degree centrality (sDC, dDC).
- Examined three frequency bands: classical, slow-4, and slow-5.
Main Results:
- CTN patients exhibited altered brain regions across three frequency bands compared to HCs.
- The classical and slow-4 frequency bands showed the most significant alterations.
- Specific regions like Cerebellum_8_L/R, Calcarine_R, and Caudate_R were unique to the classical band, while Precuneus_L and Frontal_Inf_Tri_L were unique to the slow-4 band.
- Overlapping alterations were observed in the classical and slow-4 bands for other regions.
- Brain function indicators (static and dynamic) were complementary and showed frequency specificity.
- Altered brain regions correlated with clinical parameters and mental health.
Conclusions:
- Brain function, particularly in the classical and slow-4 frequency bands, is significantly affected in CTN.
- Static and dynamic brain activity measures provide complementary insights into CTN pathophysiology.
- The slow-4 frequency band appears more consistent with the classical band, offering potential for future research into CTN.
- Findings highlight the importance of considering frequency specificity in neuroimaging studies of CTN.
