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A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
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An evolutionary perspective on complex neuropsychiatric disease

Jon M McClellan1, Anthony W Zoghbi2, Joseph D Buxbaum3

  • 1Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA.

Neuron
|November 28, 2023
PubMed

Keywords:
22q11 deletionOCDassortative matingautismbipolar disordercausalityclinical heterogeneitycomplex neuropsychiatric diseaseconsanguinityde novo mutationevolutiongenetic driftgeneticsgenomicsmigrationpolygenic inheritancerare allelesschizophreniaselectionsomatic mutation

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