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Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
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Long-Acting Ocular Injectables: Are We Looking In The Right Direction?
Mickael Dang1,2, Molly S Shoichet1,2,3
1Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 29, 2023
Summary
Biomaterial-based long-acting injectables (LAIs) offer a promising solution for ocular drug delivery challenges. These advanced formulations enhance drug residence time and bioavailability, improving therapeutic outcomes for eye conditions.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Pharmaceutics
Background:
- Ocular drug delivery faces significant hurdles due to the eye's complex anatomy and physiological barriers.
- Rapid clearance and poor drug bioavailability limit the efficacy of conventional ocular therapeutics.
Purpose of the Study:
- To review promising long-acting injectables (LAIs) for ocular drug delivery.
- To explore novel design strategies for enhancing therapeutic outcomes in ocular tissues.
Main Methods:
- Review of current literature on biomaterial-based LAIs for ocular applications.
- Analysis of design strategies for sustained drug release and targeted delivery.
Main Results:
- LAIs demonstrate potential for sustained therapeutic effects and extended local drug residence time.
- Engineered LAIs can improve drug targeting and penetration across ocular barriers.
Conclusions:
- Biomaterial-based LAIs represent a significant advancement in overcoming ocular drug delivery limitations.
- These innovative approaches hold promise for improved treatment of ocular diseases.
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