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Updated: Jul 9, 2025

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Citation network analysis on keratoconus.

Cesar Villa-Collar¹, Cristina Alvarez-Peregrina², Clara Martinez-Perez³

¹School of Biomedical and Health Science, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, Spain.

Journal of Optometry

|November 30, 2023

Summary

This summary is machine-generated.

This bibliometric analysis maps keratoconus research, identifying key publications and five core research areas. Citation networks reveal the field

Keywords:

Collagen cross-linking Keratoconus Keratoplasty

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Area of Science:

Ophthalmology
Bibliometrics
Corneal Diseases

Background:

Keratoconus is a prevalent corneal disease with ongoing debates regarding its management, etiology, and pathogenesis.
Understanding the research landscape is crucial for advancing the field.

Purpose of the Study:

To analyze publication and author relationships using citation networks.
To identify key research areas and the most influential publications in keratoconus research.

Main Methods:

A comprehensive literature search was conducted on the Web of Science database for publications on "Keratoconus" from 1900 to December 2022.
Citation Network Explorer and CiteSpace software were utilized for bibliometric analysis.

Main Results:

A total of 9,655 publications and 124,379 citations were analyzed.
2021 saw the highest number of publications.
The most cited article was "Keratoconus" by Rabinowitz (1998).
Five main research clusters were identified: corneal signs/parameters, cross-linking, clinical factors, keratoplasty, and treatment.

Conclusions:

Citation network analysis provides an objective and comprehensive overview of the scientific literature on keratoconus.
This mapping aids in understanding the evolution and structure of keratoconus research.