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Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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[Precision medicine in infectious diseases].

N Jung¹, P Schommers², C Leisse²

¹Universität zu Köln, Medizinische Fakultät und Uniklinik Köln, Klinik I für Innere Medizin, Infektiologie, Köln, Deutschland. norma.jung@uk-koeln.de.

Innere Medizin (Heidelberg, Germany)

|December 1, 2023

Summary

Precision medicine offers targeted diagnostics and personalized treatments to combat infectious disease challenges like antibiotic resistance. This approach ensures the right tests and actions for optimal patient management in infectious medicine.

Keywords:

Anti-bacterial antibodies Antimicrobial stewardship Drug resistance, multiple, bacterial Phage therapy Point-of-care testing

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Area of Science:

Infectious Disease Medicine
Precision Medicine
Antimicrobial Resistance

Context:

Rising antibiotic resistance and emerging infectious diseases pose significant global health threats.
Climate change and globalization exacerbate the spread of infectious diseases.
Current diagnostic and treatment strategies in infectious medicine face limitations.

Purpose:

To explore the application of precision medicine in addressing challenges in infectious medicine.
To highlight the importance of targeted diagnostics and patient-specific management.
To introduce novel diagnostic and therapeutic advancements in bacterial infection treatment.

Summary:

Precision medicine offers a solution by advocating for targeted diagnostics and considering individual patient characteristics for optimized management.
Molecular genetic methods provide faster results than traditional cultures for rapid bacterial infection detection.
Emerging therapeutics like bacteriophages, antibodies, and antibacterial peptides enable more precise treatment of bacterial infections.

Impact:

Precision medicine can help curb the overuse of non-indicated antibiotics by ensuring clinically relevant test results.
The integration of precision medicine is expected to significantly improve patient outcomes in infectious disease management.
Advancements in diagnostics and therapeutics will enhance the specificity and efficacy of treating bacterial infections.