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Related Experiment Videos

BHA study in pigs.

G Würtzen, P Olsen

    Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
    |October 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Butylated hydroxyanisole (BHA) did not impact piglet development or birth defects. However, high doses of BHA caused reduced maternal weight gain and increased organ weights in pregnant pigs.

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    Area of Science:

    • Toxicology
    • Reproductive Toxicology
    • Animal Science

    Background:

    • Butylated hydroxyanisole (BHA) is a synthetic antioxidant used in food preservation.
    • Understanding the reproductive and developmental effects of BHA is crucial for food safety assessments.

    Purpose of the Study:

    • To evaluate the effects of Butylated hydroxyanisole (BHA) on reproductive parameters and fetal development in pregnant pigs.

    Main Methods:

    • Pregnant SPF pigs were administered varying doses of BHA (0, 50, 200, 400 mg/kg/day) from mating to day 110 of gestation.
    • Reproductive data and fetal examinations were conducted via Caesarean section on day 110.
    • Maternal weight gain and organ weights (liver, thyroid) were assessed.

    Main Results:

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    • BHA administration did not affect reproductive success or the incidence of fetal defects.
    • A dose-dependent decrease in maternal weight gain was observed at the highest BHA dose.
    • Dose-related increases in absolute and relative liver and thyroid weights were noted.
    • Epithelial changes in the stomach and esophagus were observed, but no papillomas or glandular stomach alterations.

    Conclusions:

    • Butylated hydroxyanisole (BHA) does not appear to pose a significant risk to reproductive outcomes or fetal development in pigs at the tested doses.
    • Maternal exposure to high levels of BHA may lead to reduced weight gain and organ weight changes.