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Updated: Jul 9, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Using digital assessment technology to detect neuropsychological problems in primary care settings.
David J Libon1,2, Emily Frances Matusz3, Stephanie Cosentino4
1School of Osteopathic Medicine, New Jersey Institute for Successful Aging, Rowan University, Stratford, NJ, United States.
The Core Cognitive Evaluation™ (CCE) effectively screens for cognitive impairment and psychological distress in primary care. It identifies patients with memory concerns or cardiovascular risks who need further evaluation.
Area of Science:
- Neuroscience
- Gerontology
- Primary Care Medicine
Background:
- Screening for neurocognitive impairment and psychological distress is crucial in ambulatory care settings.
- The Core Cognitive Evaluation™ (CCE) is a novel iPad-administered tool designed for rapid assessment.
Purpose of the Study:
- To evaluate the effectiveness of the CCE in identifying neurocognitive impairment and psychological distress in a primary care setting.
- To determine the correlation between patient-reported concerns and CCE performance.
Main Methods:
- 199 ambulatory patients were screened using the CCE, which includes memory recall, clock drawing, lifestyle/health questions, and psychological distress queries.
- The CCE assesses 44 digital clock variables and provides summary indices.
Main Results:
- 41% of patients reported memory concerns, and 31% reported psychological distress.
- Patients with memory concerns scored lower on memory and clock drawing indices (p < 0.050).
- Patients with diabetes or atherosclerotic cardiovascular disease (ASCVD) also showed lower scores on specific CCE measures (p < 0.035).
Conclusions:
- The CCE is a reliable and sensitive tool for detecting cognitive decline, mood symptoms, and cardiovascular risks in outpatient settings.
- Its iPad administration ensures consistent scoring and efficient deployment in primary care.
- The CCE aids in identifying patients needing further neurocognitive and psychological assessment.
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