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Updated: Jul 9, 2025
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Impact of renal recovery on in-hospital and post-discharge mortality
Alberto Augusto Martins Paiva1, Marcia Cristina da Silva Magro1, Paulo Percio Mota Magro2
1Universidade de Brasília, Faculdade de Ceilândia, Brasília, DF, Brazil.
Objective:
To verify the impact of renal recovery on mortality in non-critically ill patients with acute kidney injury.
Method:
A prospective cohort study was carried out in a public hospital in the Federal District with patients with acute kidney injury admitted to a non-critical care unit. Renal recovery was assessed based on the ratio of serum creatinine to baseline creatinine and the patient was followed up for 6 months. Mortality was assessed during hospitalization and after discharge.
Results:
Of the 90 patients with hospital-acquired kidney injury, renal recovery was identified in 34.1% to 75% of cases, depending on the time of assessment, considering a follow-up period of up to 6 months. Recovery of renal function during follow-up had an impact on in-hospital mortality [95% CI 0.15 (0.003 - 0.73; p = 0019).
Conclusion:
Recovery of renal function has been shown to be a protective factor for mortality in patients admitted to the non-critical care unit. Early identification of kidney damage and monitoring of physiological and laboratory variables proved to be fundamental in identifying the severity of the disease and reducing mortality.
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