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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Clinically Approved Antibiotics from 2010 to 2022
1University of Zurich, Department of Chemistry, Winterthurerstrasse 190, CH-8057 Zurich. erik.jung@chem.uzh.ch.
This review covers small molecule antibiotics approved between 2010 and 2022. It details synthetic antibiotics, natural product derivatives, and natural products, highlighting key drug approvals in this period.
Area of Science:
- Pharmacology and Infectious Diseases
- Drug Discovery and Development
Background:
- The period 2010-2022 witnessed significant advancements in the development of novel small molecule antibiotics.
- Antimicrobial resistance necessitates the continuous introduction of new therapeutic agents.
- Small molecule antibiotics represent a crucial class of drugs for combating bacterial infections.
Conclusions:
- The period 2010-2022 saw a diverse range of small molecule antibiotics enter clinical use.
- The approved drugs include both novel synthetic compounds and modifications of existing natural products.
- These approvals offer new treatment options for various bacterial infections.
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