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Related Experiment Video

Updated: Jul 9, 2025

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Published on: January 21, 2018

Cardiac dysfunction in solid tumours: scoping review.

Bernadette Brady^1,2, Alexandra Brown², Michelle Barrett³

¹Academic Department of Palliative Medicine, Our Lady's Hospice & Care Services, Dublin, Ireland bbrady@olh.ie.

BMJ Supportive & Palliative Care

|December 5, 2023

Summary

This summary is machine-generated.

Cancer can harm the heart independently of treatment. This study found cardiovascular abnormalities like cardiomyopathy and autonomic nervous system dysfunction in cancer patients, impacting prognosis and requiring wider screening.

Keywords:

Cancer Heart failure Paraneoplastic disorders Quality of life Supportive care

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Last Updated: Jul 9, 2025

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Displacement Analysis of Myocardial Mechanical Deformation DIAMOND Reveals Segmental Heterogeneity of Cardiac Function in Embryonic Zebrafish

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Published on: February 6, 2020

Area of Science:

Cardio-oncology
Cardiovascular Medicine
Oncology

Background:

Cancer can independently damage the heart, separate from cancer treatment-related cardiac dysfunction (CTRCD).
Understanding these intrinsic cardiac risks is crucial for comprehensive patient care.

Purpose of the Study:

To identify and characterize cardiovascular abnormalities in adult patients with solid tumors, excluding CTRCD.
To synthesize existing evidence on the nature and impact of cancer-associated cardiac issues.

Main Methods:

A comprehensive scoping review was conducted across CINAHL, Embase, and Medline databases, supplemented by handsearching.
Forty-four studies were included after rigorous screening and data extraction by two researchers.
Narrative synthesis was employed due to the heterogeneity of the identified studies.

Main Results:

Cardiovascular abnormalities identified include cardiomyopathy (16 studies), autonomic nervous system dysfunction (10 studies), and biomarker disturbances (9 studies).
These abnormalities were linked to significant morbidity (e.g., chest pain, dyspnea, fatigue) and a poorer prognosis.
Prevalence could not be determined due to variable study designs.

Conclusions:

Cardiovascular dysfunction occurs in solid tumor malignancies independently of CTRCD, even in treatment-naïve patients.
Manifestations include cardiomyopathies, autonomic dysfunction, and elevated biomarkers, leading to symptoms and reduced survival.
Clinical practice should integrate these findings, expanding screening criteria to address intrinsic cardiac risks.