Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K
Glaucoma: Overview01:25

Glaucoma: Overview

592
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
592
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

456
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
456
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

515
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
515

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

THRIVE: A Phase 3, Randomized, Double-Masked, Placebo-Controlled Study of Veligrotug for Active Thyroid Eye Disease.

Ophthalmology·2026
Same author

Unveiling the psychological impact of visual impairment in young and middle-aged adults: a concept mapping study.

BMC psychology·2026
Same author

Management of Visual Loss Following Hyaluronic Acid Filler Injections: An Algorithm-based Approach.

Plastic and reconstructive surgery. Global open·2026
Same author

Orbital Rhabdomyosarcoma: A Comprehensive Review of Clinical Features, Molecular Advances and Current Management.

Clinical & experimental ophthalmology·2026
Same author

Corticosteroids Versus Teprotumumab for the Treatment of Thyroid Eye Disease. Does Either Mitigate the Need for Additional Treatments?

Thyroid : official journal of the American Thyroid Association·2025
Same author

Assessment of disease activity in Graves' orbitopathy.

Frontiers in ophthalmology·2025
Same journal

Orbital Inflammatory Syndrome Associated with Bispecific T-Cell Engager Therapy: Case and Literature Review.

Ophthalmic plastic and reconstructive surgery·2026
Same journal

A Rare Pedunculated Lobular Capillary Hemangioma of the Conjunctiva.

Ophthalmic plastic and reconstructive surgery·2026
Same journal

Core Oculoplastic Procedure Skills for the Comprehensive Ophthalmologist: A Consensus by Delphi Methodology.

Ophthalmic plastic and reconstructive surgery·2026
Same journal

The Role of Corneal Sensation in Facial Nerve Paralysis.

Ophthalmic plastic and reconstructive surgery·2026
Same journal

Lacrimal Gland Dacryolithiasis With Secondary Bacterial Dacryoadenitis: Clinicoradiological Characterization and Review of Literature.

Ophthalmic plastic and reconstructive surgery·2026
Same journal

Aprepitant for Oculoplastic Surgeries.

Ophthalmic plastic and reconstructive surgery·2026
See all related articles

Related Experiment Video

Updated: Jul 9, 2025

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

19.3K

Dysthyroid Optic Neuropathy.

Arnaud R G G Potvin1, Farzad Pakdel2, Peerooz Saeed1

  • 1Orbital Center Amsterdam, Department of Ophthalmology, Amsterdam University Medical Center, location AMC, The Netherlands.

Ophthalmic Plastic and Reconstructive Surgery
|December 6, 2023
PubMed
Summary
This summary is machine-generated.

Dysthyroid optic neuropathy (DON), a severe complication of thyroid eye disease (TED), requires prompt diagnosis and multidisciplinary management. While glucocorticoids are first-line, novel biologics offer future therapeutic potential for this sight-threatening condition.

More Related Videos

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition
06:09

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

Published on: August 18, 2023

1.6K
The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy rNAION
06:49

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy rNAION

Published on: November 20, 2016

9.0K

Related Experiment Videos

Last Updated: Jul 9, 2025

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

19.3K
Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition
06:09

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

Published on: August 18, 2023

1.6K
The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy rNAION
06:49

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy rNAION

Published on: November 20, 2016

9.0K

Area of Science:

  • Ophthalmology
  • Endocrinology
  • Neurology

Background:

  • Dysthyroid optic neuropathy (DON) is a critical sight-threatening complication of thyroid eye disease (TED), affecting 5-8% of patients.
  • Apical optic nerve compression is the primary pathogenic mechanism, with age, male gender, smoking, and diabetes as risk factors.

Approach:

  • This review synthesizes current literature on DON epidemiology, pathogenesis, diagnostic criteria, and therapeutic strategies.
  • Diagnostic confirmation involves clinical findings (visual acuity, color vision, pupillary defect, visual fields, disc edema) and orbital imaging (apical crowding, nerve stretching).

Key Points:

  • Prompt diagnosis and multidisciplinary management are crucial to prevent irreversible vision loss.
  • High-dose intravenous glucocorticoids (methylprednisolone) are the first-line treatment.
  • Surgical decompression is reserved for treatment failures, while radiotherapy may aid prevention.

Conclusions:

  • Despite prompt management, DON can lead to permanent visual impairment.
  • Intravenous methylprednisolone remains the primary therapy, with surgery as a secondary option.
  • Biologic agents represent a promising future avenue for DON management, requiring further investigation.