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Updated: Jul 9, 2025

Synthesis of 1,2-Azaborines and the Preparation of Their Protein Complexes with T4 Lysozyme Mutants
Published on: March 25, 2017
Borylation-Reduction-Borylation for the Formation of 1,4-Azaborines
Shantaram S Kothavale1, Saqib A Iqbal1, Emily L Hanover1,2
1EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, United Kingdom.
Abstract:
Given the current interest in materials containing 1,4-azaborine units, the development of new routes to these structures is important. Carbonyl directed electrophilic borylation using BBr3 is a facile method for the ortho-borylation of N,N-diaryl-amide derivatives. Subsequent addition of Et3SiH results in carbonyl reduction and then formation of 1,4-azaborines that can be protected in situ using a Grignard reagent. Overall, borylation-reduction-borylation is a one-pot methodology to access 1,4-azaborines from simple precursors.
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