Female Hyperplastic PSA-Positive Prostate Tissue in the Bladder Neck.
Radion Garaz1, Arnulf Stenzl1, Stephan Singer2
1Department of Urology, University Hospital of Tuebingen, Tuebingen, Germany.
Urologia Internationalis
|December 6, 2023
Summary
This case study details a rare instance of Skene's gland hyperplasia in a 91-year-old woman, presenting with measurable prostate-specific antigen (PSA) levels. Surgical intervention via transurethral resection proved effective, with no recurrence observed.
Area of Science:
- Urology
- Gynecologic Pathology
Background:
- Skene's gland hyperplasia is a rare condition.
- This report highlights a case with measurable serum prostate-specific antigen (PSA).
Observation:
- A 91-year-old woman presented with a suspected bladder mass obstructing the bladder neck.
- Cystoscopy revealed a large mass, and transurethral resection was performed.
- Histopathology confirmed adenomyomatous hyperplasia of the Skene's gland, identified as the "female prostate" via immunohistochemistry.
Findings:
- Postoperative serum PSA levels were measurable (0.08 ng/mL).
- Immunohistochemistry confirmed strong PSA and NKX3.1 positivity.
- FISH analysis confirmed an XX karyotype.
Implications:
- This case suggests transurethral resection as a viable treatment for Skene's gland hyperplasia.
- Further research is needed due to the rarity of this condition.
- Management should consider the patient's age and potential for PSA elevation.
