Chemically Tailored Single Atoms for Targeted and Light-Controlled Bactericidal Activity

Area of Science:

• Nanotechnology
• Materials Science
• Biomedical Engineering

Background:

• Single-atom (SA) nanoparticles possess promising photothermal properties for combating bacteria.
• Current limitations include restricted efficacy in targeted and controlled antibacterial activity, hindering practical applications.

Purpose of the Study:

• To overcome limitations in SA nanoparticle antibacterial efficacy through chemical modifications.
• To achieve targeted and light-controlled antimicrobial effects using tailored SA nanoparticles.

Main Methods:

• Atomic-level modification of palladium SAs using glutathione (GSH) and mercaptophenylboronic acid (MBA).
• Evaluation of targeted binding capabilities toward Escherichia coli cells.
• Assessment of antibacterial efficacy in inhibiting wound bacteria proliferation and promoting wound healing in a rat model under 808 nm laser irradiation.

Main Results:

• Modified SAs demonstrated superior targeted binding to Escherichia coli cells compared to cysteine-modified SAs.
• The modified SA nanoparticles effectively inhibited wound bacteria proliferation.
• Promoted wound healing in rats without significant toxicity to major organs.

Conclusions:

• Chemical engineering is crucial for tailoring SA nanoparticle antibacterial properties.
• Tailored SA nanoparticles offer a promising strategy for combating bacterial infections.
• This approach advances nanoparticle-based therapies for wound management and infection control.