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Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

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Sleep and Circadian Disturbances in Children With Neurodevelopmental Disorders.

Sharon Tamir¹, Thomas J Dye², Rochelle M Witt²

¹University of Cincinnati College of Medicine, Cincinnati, OH; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Seminars in Pediatric Neurology

|December 8, 2023

Summary

Sleep problems are common in neurodevelopmental disorders (NDDs). These issues stem from factors impacting sleep and circadian rhythms, potentially causing a "developmental and sleep/circadian-related encephalopathy."

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Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

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Published on: August 8, 2019

Area of Science:

Neuroscience
Developmental Biology
Sleep Medicine

Background:

Sleep problems are highly prevalent in individuals with neurodevelopmental disorders (NDDs).
These sleep disturbances are hypothesized to arise from multiple factors impacting sleep and circadian processes.
This bidirectional relationship may lead to a
developmental and sleep/circadian-related encephalopathy.

Approach:

This review examines specific NDDs with identified or suspected sleep and circadian phenotypes.
It highlights critical factors in assessing and managing sleep and circadian disorders within these populations.
The review synthesizes current understanding of sleep disturbances in NDDs.

Key Points:

Neurodevelopmental disorders (NDDs) frequently present with sleep and circadian rhythm disruptions.
These disruptions can exacerbate developmental trajectories and neurological function.
Understanding these phenotypes is crucial for effective clinical management.

Conclusions:

Sleep and circadian dysregulation is a significant, often overlooked, issue in NDDs.
Addressing sleep problems is essential for improving overall development and neurological health in NDD populations.
Further research and tailored interventions are needed for sleep and circadian disorders in NDDs.