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Sleep and Circadian Disturbances in Children With Neurodevelopmental Disorders

Sharon Tamir1, Thomas J Dye2, Rochelle M Witt2

  • 1University of Cincinnati College of Medicine, Cincinnati, OH; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Seminars in Pediatric Neurology
|December 8, 2023
PubMed

Insights

Sleep problems are common in neurodevelopmental disorders (NDDs). These issues stem from factors impacting sleep and circadian rhythms, potentially causing a "developmental and sleep/circadian-related encephalopathy."

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Sleep Medicine

Background:

  • Sleep problems are highly prevalent in individuals with neurodevelopmental disorders (NDDs).
  • These sleep disturbances are hypothesized to arise from multiple factors impacting sleep and circadian processes.
  • This bidirectional relationship may lead to a
  • developmental and sleep/circadian-related encephalopathy.

Approach:

  • This review examines specific NDDs with identified or suspected sleep and circadian phenotypes.
  • It highlights critical factors in assessing and managing sleep and circadian disorders within these populations.
  • The review synthesizes current understanding of sleep disturbances in NDDs.

Key Points:

  • Neurodevelopmental disorders (NDDs) frequently present with sleep and circadian rhythm disruptions.
  • These disruptions can exacerbate developmental trajectories and neurological function.
  • Understanding these phenotypes is crucial for effective clinical management.

Conclusions:

  • Sleep and circadian dysregulation is a significant, often overlooked, issue in NDDs.
  • Addressing sleep problems is essential for improving overall development and neurological health in NDD populations.
  • Further research and tailored interventions are needed for sleep and circadian disorders in NDDs.

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