Evaluation of Micronutrients and Pro-Inflammatory Cytokines Levels in Nutritionally Deprived Children-A Tertiary Care
Malvika Mishra1, Alok Raghav2, Prashant Tripathi3
1Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India.
Insights
Severe acute malnutrition (SAM) in children is linked to lower zinc levels and higher inflammation. Antibiotic treatment alongside nutritional support significantly improves outcomes in SAM children without complications.
Area of Science:
- Pediatrics
- Public Health
- Nutritional Science
Background:
- Severe acute malnutrition (SAM) poses a significant public health challenge, particularly in developing nations like India.
- A substantial number of children in India are affected by malnutrition, necessitating research into its contributing factors and management.
Purpose of the Study:
- To investigate factors contributing to severe acute malnutrition (SAM).
- To explore the relationship between micronutrient status and pro-inflammatory cytokines in SAM children, with and without complications.
- To evaluate the effectiveness of antibiotic treatment in SAM children without complications.
Main Methods:
- The study included 198 participants divided into three groups: healthy controls, SAM children with complications, and SAM children without complications (66 subjects per group).
- Blood samples were analyzed for biochemical, hematological, micronutrient, and pro-inflammatory marker levels.
- Statistical analysis was performed using SPSS version 22.0.
Main Results:
- SAM children with complications exhibited significantly higher levels of IL-6, CRP, and TNF-α compared to controls and SAM children without complications.
- Both SAM groups showed significantly lower zinc and copper levels than controls, with a negative correlation between zinc and inflammatory markers.
- Antibiotic treatment and nutritional support led to significant improvements in weight, height, and nutritional indices in SAM children without complications after 15 days.
Conclusions:
- Combined antibiotic treatment and nutritional support demonstrate significant clinical benefits for SAM children without complications.
- These findings offer valuable insights for improving the management and treatment strategies for SAM in India and other developing countries.
Background:
Severe acute malnutrition (SAM) is a significant public health problem in developing countries, including India, where a significant proportion of children suffer from malnutrition.
Objective:
This research aims to investigate the factors contributing to severe acute malnutrition (SAM). Additionally, the study seeks to explore the relationship between micronutrient levels and pro-inflammatory cytokines in SAM children with and without clinical complications. Furthermore, the effectiveness of antibiotic treatment in SAM children without complications is evaluated.
Methods:
The study involved three groups comprising 66 subjects each: a healthy control group, SAM children with complications, and SAM children without complications. Blood samples were collected, and various analyses were conducted, including biochemical, hematological, micronutrient, and pro-inflammatory marker quantification. The data were analyzed using SPSS version 22.0.
Results:
The results indicate that the levels of IL-6, CRP, and TNF-α were significantly higher in the SAM group with complications compared to both the control group and the SAM group without complications. Zinc and copper levels were significantly lower in both SAM groups compared to the control group, and a negative correlation was observed between zinc levels and inflammatory markers. The study also assessed the efficacy of antibiotic treatment in SAM children without complications by comparing their weight, height, weight-for-height, and weight-for-age at baseline and after a 15-day follow-up period. Significant improvements in these parameters were observed in both the group receiving antibiotic treatment and the group not receiving antibiotic treatment.
Conclusion:
The findings suggest that a combination of antibiotic treatment and nutritional support can lead to significant clinical improvements in SAM children without complications. This study has important implications for the management and treatment of SAM in India and other developing countries.
More Related Videos
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
00:04A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
