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Updated: Jul 9, 2025

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Advance in Targeted Cancer Therapy and Mechanisms of Resistance

Patrick Ming-Kuen Tang1, Dongmei Zhang2

  • 1State Key Laboratory of Translational Oncology, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.

International Journal of Molecular Sciences
|December 9, 2023
PubMed

Insights

Drug resistance is a major hurdle in cancer treatment, leading to poor patient outcomes. Understanding and overcoming this resistance is crucial for improving cancer survival rates globally.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Drug resistance is a significant clinical challenge in cancer therapy.
  • It contributes to the high global mortality rates associated with cancer.
  • Developing strategies to overcome drug resistance is a critical research area.

Discussion:

  • Mechanisms of drug resistance are complex and multifactorial.
  • Identifying predictive biomarkers for drug response is essential.
  • Exploring novel therapeutic approaches is necessary to combat resistance.

Key Insights:

  • This study investigates key factors contributing to cancer drug resistance.
  • Findings shed light on specific molecular pathways involved in treatment failure.
  • The research provides a foundation for developing more effective cancer therapies.

Outlook:

  • Future research should focus on combination therapies to circumvent resistance.
  • Clinical trials are needed to validate new strategies in patient populations.
  • Advancements in personalized medicine hold promise for overcoming drug resistance.

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