Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cochlear action potentials threshold and systemic arterial pO2.

M Hildesheimer, C Muchnik, M Rubinstein

    The Laryngoscope
    |February 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Functional redundancy and compensation: Deletion of multiple murine Crisp genes reveals their essential role for male fertility.

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2020
    Same author

    Discriminating value of HR-pQCT for fractures in women with similar FRAX scores: A substudy of the FRISBEE cohort.

    Bone·2020
    Same author

    Osteoporosis treatment gap in a prospective cohort of volunteer women.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
    Same author

    Unexpected Stretching of Entangled Ring Macromolecules.

    Physical review letters·2019
    Same author

    Distribution of clinical risk factors for fracture in a Brussels cohort of postmenopausal women: The FRISBEE study and comparison with other major cohort studies.

    Maturitas·2017
    Same author

    Association of rare missense variants in the second intracellular loop of Na<sub>V</sub>1.7 sodium channels with familial autism.

    Molecular psychiatry·2016
    Same journal

    Association Between the Modified Frailty Index and Short-Term Total Thyroidectomy Complications.

    The Laryngoscope·2026
    Same journal

    Discrimination of Pairs of Chemosensory Stimuli in Relation to Respiration.

    The Laryngoscope·2026
    Same journal

    What Safety Precautions Are Recommended When Lasering in the Airway?

    The Laryngoscope·2026
    Same journal

    Success of Anterior Ethmoidal Artery Flaps for Nasal Septal Perforation Repair: A Systematic Review.

    The Laryngoscope·2026
    Same journal

    Laryngeal IgG4-Related Disease: A Systematic Review of Clinical Features and Management.

    The Laryngoscope·2026
    Same journal

    Elevated BMI Is Not Associated With Adverse Outcomes in Open Airway Reconstruction.

    The Laryngoscope·2026
    See all related articles

    Hypoxemia, or low oxygen levels, progressively impairs guinea pig hearing. A critical arterial oxygen level of 30 mm Hg was identified, below which cochlear function significantly deteriorates, impacting auditory potentials.

    Area of Science:

    • Auditory Neuroscience
    • Physiology
    • Otoacoustic Emissions

    Background:

    • Hypoxemia is a condition characterized by abnormally low oxygen levels in the blood.
    • The auditory system, particularly the cochlea, is highly sensitive to oxygen deprivation.
    • Understanding the threshold for cochlear dysfunction during hypoxemia is crucial for auditory health research.

    Purpose of the Study:

    • To investigate the effects of progressive hypoxemia on cochlear function in guinea pigs.
    • To determine the critical arterial oxygen level (pO2) at which auditory potentials begin to deteriorate.
    • To characterize the changes in cochlear action potentials (CAP) under varying degrees of hypoxia.

    Main Methods:

    • Progressive hypoxemia was induced in Hartley guinea pigs by rebreathing air in a closed circuit with continuous CO2 absorption.

    Related Experiment Videos

  • Cochlear action potentials (CAP) were recorded at different stimulus intensities.
  • Mean arterial pO2 levels were monitored throughout the experiment.

    • Main Results:

    • Fluctuations in CAP were observed near the hearing threshold at a mean arterial pO2 of 30 mm Hg in 60% of guinea pigs.
    • A significant shift in the CAP threshold occurred in all subjects at a mean pO2 of 24.66 mm Hg.
    • No CAP response was elicited at a mean pO2 of 14.92 mm Hg, even at high sound pressure levels.

    Conclusions:

    • A mean arterial pO2 of 30 mm Hg represents a critical level for the onset of cochlear dysfunction in guinea pigs.
    • Progressive hypoxemia leads to a dose-dependent impairment of auditory nerve function.
    • These findings highlight the vulnerability of the cochlea to oxygen deprivation and provide a threshold for auditory damage.