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Updated: Jul 23, 2026
06:54
MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
Published on: September 3, 2013
11.3K
Elevated prostate-specific antigen in Paget's disease
Shrikant Vasantrao Solav1, Manohar Inamdar2, Shailendra V Savale2
1Department of Nuclear Medicine, SPECTLAB Nuclear Medicine Services, Pune, India.
Summary
A prostate cancer patient
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- A 70-year-old man with advanced prostate cancer (Gleason 8) presented with elevated prostate-specific antigen (PSA).
- Bone scintigraphy was performed to assess for bone metastases.
Observation:
- Bone scan showed increased tracer uptake in the right hemipelvis, mimicking bone metastases.
- Gallium-68-prostate-specific membrane antigen (PSMA) PET-CT was utilized for further evaluation.
Findings:
- The PSMA PET-CT identified a primary prostate tumor but revealed no PSMA uptake in the sclerotic right hemipelvis.
- This finding excluded prostate cancer metastasis to the right hemipelvis and confirmed Paget's disease of bone.
Implications:
- This case highlights the importance of correlating imaging findings with specific molecular markers.
- PSMA PET-CT can differentiate bone metastases from other bone pathologies like Paget's disease in prostate cancer patients.
- Accurate diagnosis is crucial for appropriate patient management and treatment planning.
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