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Related Experiment Video

Updated: Jul 23, 2026

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

Elevated prostate-specific antigen in Paget's disease.

Shrikant Vasantrao Solav¹, Manohar Inamdar², Shailendra V Savale²

¹Department of Nuclear Medicine, SPECTLAB Nuclear Medicine Services, Pune, India.

Indian Journal of Urology : IJU : Journal of the Urological Society of India

|December 11, 2023

Summary

A prostate cancer patient

Area of Science:

Oncology
Nuclear Medicine
Radiology

Background:

A 70-year-old man with advanced prostate cancer (Gleason 8) presented with elevated prostate-specific antigen (PSA).
Bone scintigraphy was performed to assess for bone metastases.

Observation:

Bone scan showed increased tracer uptake in the right hemipelvis, mimicking bone metastases.
Gallium-68-prostate-specific membrane antigen (PSMA) PET-CT was utilized for further evaluation.

Findings:

The PSMA PET-CT identified a primary prostate tumor but revealed no PSMA uptake in the sclerotic right hemipelvis.
This finding excluded prostate cancer metastasis to the right hemipelvis and confirmed Paget's disease of bone.

Implications:

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This case highlights the importance of correlating imaging findings with specific molecular markers.

PSMA PET-CT can differentiate bone metastases from other bone pathologies like Paget's disease in prostate cancer patients.

Accurate diagnosis is crucial for appropriate patient management and treatment planning.