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Related Experiment Video

Updated: Jul 8, 2025

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level
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Experimental and Computational Investigation of Microbubble Formation in a Single Capillary Embedded T-junction

Aaqib H Khan1, Arijit Ganguli2, Mohan Edirisinghe3

  • 1Chemical Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, Gujarat 382355, India.

Langmuir : the ACS Journal of Surfaces and Colloids
|December 13, 2023
PubMed
Summary

Capillary-embedded T-junction microfluidic devices offer precise control over microbubble synthesis. This study investigates microbubble formation in these devices, finding that increased liquid and gas velocities enhance production rates and allow for size reduction.

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Area of Science:

  • Microfluidics
  • Fluid Dynamics
  • Materials Science

Background:

  • Microfluidic devices are increasingly used for microbubble synthesis due to precise size control.
  • Capillary-embedded T-junction microfluidic (CETM) devices, featuring a unique backflow, are effective for microbubble generation.

Purpose of the Study:

  • To experimentally and computationally investigate microbubble formation in CETM devices.
  • To understand the impact of backflow on microbubble characteristics.

Main Methods:

  • Computational fluid dynamics (CFD) modeling using the volume-of-fluid approach.
  • Experimental analysis of microbubble formation under varying gas and liquid velocities.

Main Results:

  • Increased liquid and gas velocities enhance microbubble production rates.
  • Simulations closely matched experimental findings for microbubble size variation with liquid velocity (CV=10%).
  • Pressure fluctuations exhibited recurrent patterns during microbubble generation.

Conclusions:

  • Understanding backflow in CETM devices is key to improving microbubble size reduction.
  • This research provides insights for optimizing microfluidic synthesis of microbubbles.