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Updated: Aug 1, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Acute intracranial stenting in acute ischemic stroke with underlying atherosclerosis: A two-center retrospective
Sofia Bettencourt1, Muhammed A Essibayi2, Mariana Baptista1,3
1Neuroradiology Department, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.
Insights
Acute intracranial stenting after mechanical thrombectomy is safe and effective for acute stroke patients with intracranial atherosclerotic disease (ICAD). Younger age predicts better outcomes, though ICAD remains associated with high mortality and poor functional results.
Area of Science:
- Neurology
- Interventional Neuroradiology
- Vascular Neurology
Background:
- Successful reperfusion in large vessel occlusion stroke predicts favorable outcomes.
- Intracranial atherosclerotic disease (ICAD) increases the risk of reocclusion after mechanical thrombectomy (MT), often necessitating rescue stenting.
Purpose of the Study:
- To investigate the safety, efficacy, and outcomes of acute intracranial stenting in acute stroke patients with underlying ICAD.
- To evaluate the role of rescue stenting in patients with ICAD undergoing MT.
Main Methods:
- A prospective review of databases from two centers (2012-2021) included adult patients undergoing ICAD-related acute intracranial stenting post-MT.
- Data collected included clinical and procedural details, technical success (Modified Thrombolysis in Cerebral Infarction score), complications, restenosis, and 3-month modified Rankin Scale (mRS) scores.
Main Results:
- Ninety-six patients with acute stroke and ICAD underwent stenting post-MT.
- Successful reperfusion (TICI ≥ 2b) was achieved in 89.6% of patients.
- Favorable functional outcome (mRS < 3) was observed in 37.6% of patients; older age was a negative predictor (OR: 0.477, p=0.046).
- Symptomatic intracranial hemorrhage occurred in 9.5%, and mortality was 22.4%.
Conclusions:
- Acute intracranial stenting is a safe and effective rescue treatment post-MT for acute stroke patients with ICAD.
- Younger age is an independent predictor of favorable functional outcomes.
- Despite treatment, ICAD remains associated with significant mortality and poor functional outcomes.
Abstract:
ObjectiveIn patients with large vessel occlusion, successful reperfusion is a predictor of favorable outcome. However, patients with underlying intracranial atherosclerotic disease (ICAD) show higher rates of immediate reocclusion, frequently requiring rescue stenting. We aimed to investigate the safety, efficacy, and outcome of acute stenting in acute stroke patients with underlying ICAD.MethodsProspective databases from two centers between 2012 and 2021 were reviewed. Adult patients who underwent ICAD-related acute intracranial stenting, after mechanical thrombectomy (MT) were included. Clinical and procedural data, technical success measured by Modified Thrombolysis in Cerebral Infarction score, periprocedural complications, stent restenosis, and follow up mRS at three months were evaluated.ResultsDuring a 10-year period, a total of 96 patients with acute stroke and intracranial atherosclerotic steno-occlusive lesions underwent stenting after MT. Mean age was 63 (SD 14) and 54 patients were male (56.3%). Successful reperfusion (TICI ≥ 2b) was achieved in 86 patients (89.6%) following rescue stenting; favorable clinical outcome (mRS < 3) was observed in 32 patients (37.6%). Symptomatic intracranial hemorrhage and mortality were observed in 9.5% and 22.4% of patients, respectively. Multivariate regression yielded older age (OR: 0.477, 95% CI: 0.933-0.999, p=0.046) as an independent negative predictor of favorable functional outcome after acute intracranial stenting.ConclusionOur results suggest that acute intracranial stenting is safe and effective as a rescue treatment after MT in acute stroke patients with underlying ICAD. Younger age was found as an independent predictor of good outcome. Nevertheless, ICAD still carries a high mortality and poor functional clinical outcome.
