Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurulation01:30

Neurulation

42.0K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
42.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual transcriptional activities of PAX3 and PAX7 spatially encode spinal cell fates through distinct gene networks.

PLoS biology·2025
Same author

Blake Pouch: It Is Time to Revisit Classical Descriptions on the Development of the Roof of the Fourth Ventricle.

Advances and technical standards in neurosurgery·2025
Same author

A differential requirement for ciliary transition zone proteins in human and mouse neural progenitor fate specification.

Nature communications·2025
Same author

Pituitary Gland Duplication Syndrome: An International Imaging Analysis.

AJNR. American journal of neuroradiology·2024
Same author

BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas.

eLife·2024
Same author

Variations in cell plasticity and proliferation underlie distinct modes of regeneration along the antero-posterior axis in the annelid Platynereis.

Development (Cambridge, England)·2024

Related Experiment Video

Updated: Jul 8, 2025

Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons
11:52

Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons

Published on: August 26, 2021

2.3K

Stem cell-derived models of spinal neurulation.

Camil Mirdass1,2,3,4, Martin Catala5, Mikaëlle Bocel1

  • 1Université Paris Cité, CNRS, Institut Jacques Monod, F-75013 Paris, France.

Emerging Topics in Life Sciences
|December 13, 2023
PubMed
Summary

Neurulation forms the neural tube, crucial for central nervous system development. Advanced stem cell models offer new ways to study this process and related birth defects.

Keywords:
developmentepitheliumneural tubeneurodevelopmentorganoidstem cells

More Related Videos

A Neonatal Mouse Spinal Cord Compression Injury Model
13:31

A Neonatal Mouse Spinal Cord Compression Injury Model

Published on: March 27, 2016

12.6K
A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury
09:08

A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury

Published on: September 13, 2018

9.9K

Related Experiment Videos

Last Updated: Jul 8, 2025

Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons
11:52

Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons

Published on: August 26, 2021

2.3K
A Neonatal Mouse Spinal Cord Compression Injury Model
13:31

A Neonatal Mouse Spinal Cord Compression Injury Model

Published on: March 27, 2016

12.6K
A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury
09:08

A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury

Published on: September 13, 2018

9.9K

Area of Science:

  • Developmental biology
  • Tissue engineering
  • Stem cell research

Background:

  • Neurulation is a fundamental process in embryonic development, forming the neural tube, the precursor to the central nervous system.
  • Understanding neurulation is key to addressing neural tube defects, a significant category of birth defects.
  • Complex morphogenetic events drive neural tube formation, involving multiple scales and tissues.

Conclusions:

  • Stem cell-based in vitro models are powerful tools for investigating neurulation and neural tube defects.
  • Further technical developments are needed to enhance the fidelity of these models.
  • Continued research using these models promises deeper understanding of human developmental biology and pathology.