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Published on: December 18, 2012
Humanized Mice as a Model to Assess the Response of Human Hematopoietic Stem Cells to Irradiation
N I Atamanyuk1, S S Andreev2, A A Peretykin2
1Urals Research Center for Radiation Medicine, Federal Medical-Biological Agency of Russia, Chelyabinsk, Russia. vita_pulhra@mail.ru.
Abstract:
NOD SCID mice were humanized by transplanting human hematopoietic cells isolated from umbilical cord blood. A dose-dependent death of hematopoietic cells and their subsequent recovery were shown after acute external γ-irradiation in the model of humanized mice. The proposed approach can be used for preclinical studies of radioprotective agents and for assessment of the impact of adverse factors on the survival rate and functional properties of human hematopoietic stem cells in vivo.
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