ASSOCIATION OF NESFATIN-1 AND INSULIN RESISTANCE IN OBESE ADOLESCENTS OF IRAQ POPULATION

Nesfatin-1 reduces body weight and the intake of food, it is also tangled in setting insulin release. This study aims at comparing the levels of serum of Nesfatin-1 with the insulin resistance in obese adolescent of iraqi population with other nations around the world predicating development of diabetes mellitus later. 90 participants were needed for this cross-sectional study, including 30 control participants (17 men and 13 women) and 60 obese adolescents (36 men and 24 women). Serum glucose, insulin, and glycated hemoglobin in starved participants were estimated, using an ELISA kit, the serum level of Nesfatin-1 was measured, and insulin resistance was calculated. Obese adolescents aged 12 to 18 and the control group, who were between 13 and 18 years old. The level of nesfatin-1 was significantly lower in the group of obese adolescents than in the controls. The ranges of Nesfatin-1 were (1.22±0.39 n/ml vs 2.54±0.64 n/m P = 0.001). In the control and obese groups respectively. In comparison to the results of the non-obese adolescent group, the obese group has significantly lower insulin sensitivity. Serum Nesfatin-1 is negatively associated with insulin sensitivity, lipid profile, and body mass index. In general, our study revealed that there is no effect of food culture and eating intake on the role of Nesfatin -1 inducing obesity.