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Related Experiment Video

Updated: Jul 8, 2025

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention
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The Sequential Therapy in Osteoporosis.

Ravi Sauhta1, Dheeraj Makkar2, Pooja Sauhta Siwach3

  • 1Department Orthopedics and Joint Replacement, Artemis Hospitals, Gurgaon, India.

Indian Journal of Orthopaedics
|December 18, 2023
PubMed
Summary

Optimizing osteoporosis treatment involves sequential drug therapy. Starting with anabolic agents followed by antiresorptives improves bone mass more effectively than other sequences.

Keywords:
AbaloparatideBisphosphonates (BPN)Combination therapyDenosumab (D’mab)FractureFragility fracturesOsteoporosisRomosozumabScreeningSequencing therapiesSequential therapyTeriparatide (TPTD)Transitional therapyUndertreatment

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Area of Science:

  • Endocrinology
  • Pharmacology
  • Bone Biology

Background:

  • Osteoporosis management frequently employs sequential treatment strategies.
  • These strategies are individualized based on patient factors, treatment response, and fracture risk.

Purpose of the Study:

  • To evaluate the effectiveness of sequential anti-osteoporosis drug therapy.
  • To identify optimal drug sequencing for long-term osteoporosis management.

Main Methods:

  • Systematic literature review of PubMed and EMBASE databases (1995-2023).
  • Analysis of original articles and clinical trials on sequential osteoporosis drug therapy.
  • Examination of drug mechanisms, side effects, and treatment trends.

Main Results:

  • Optimal bone mass improvement achieved by initiating treatment with anabolic agents, followed by antiresorptives.
  • Starting with bisphosphonates may reduce outcomes in subsequent anabolic treatment phases.
  • Caution advised when transitioning from denosumab to PTH analogs due to potential bone turnover issues.

Conclusions:

  • Sequential treatment offers a flexible, tailored approach for osteoporosis management.
  • Optimized sequencing can enhance fracture prevention and patient outcomes.