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Red-Fluorescent Covalent Organic Framework Nanospheres for Trackable Anticancer Drug Delivery.
Wei Zhang1, Shuo Xiang1, Yanyang Long1
1College of Materials Science and Engineering, Hunan University, 2 Lushan S Rd, Changsha 410082, P. R. China.
ACS Applied Materials & Interfaces
|December 19, 2023
Summary
Researchers developed red-fluorescent covalent organic framework nanospheres (COFNSs) for drug delivery. These COFNSs show excellent tracking of anticancer drug delivery and enhance cancer treatment efficacy.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Covalent organic frameworks (COFs) are promising for drug delivery due to tunable properties.
- Existing COFs often have limitations in cellular bioavailability and luminescence.
Purpose of the Study:
- To design and synthesize size-tunable, red-fluorescent COF nanospheres (COFNSs).
- To evaluate COFNSs as trackable nanocarriers for anticancer drug delivery.
Main Methods:
- Synthesized COFNSs via Schiff-base condensation of 1,3,5-triformylbenzene (TFB) and dihydrazide blocks.
- Characterized COFNSs for size, crystallinity, and red fluorescence (647 nm).
- Assessed drug loading capacity (camptothecin - CPT) and in vitro/in vivo anticancer efficacy.
Main Results:
- Developed stable, red-fluorescent COFNSs with emission at 647 nm.
- Achieved high CPT loading capacity (183 wt %) and excellent cell viability (>90%).
- Demonstrated effective in vitro and in vivo inhibition of 4T1 cancers using COFNSs as CPT nanocarriers.
Conclusions:
- COFNSs offer integrated fluorescence and drug delivery functions for trackable cancer therapy.
- This approach provides a valuable strategy for developing advanced COF-based nanocarriers.
