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Updated: Aug 13, 2026
05:08
Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
Published on: January 31, 2022
[Pharmaco-physiologic correlations of iron-dextran complexes in laboratory animals]
Veterinarno-Meditsinski Nauki
|January 1, 1986
Summary
Iron-dextran preparations like dextrofer-100 and miofer-100 can lower blood pressure and affect heart contractions in cats. Dextrofer-100 also demonstrated protective effects against anaphylactic shock in guinea pigs and reduced edema in rats.
Area of Science:
- Pharmacology
- Toxicology
- Veterinary Medicine
Background:
- Iron-dextran complexes are widely used for treating iron deficiency anemia.
- Understanding the physiological effects and potential side effects of these preparations is crucial for safe clinical application.
Purpose of the Study:
- To investigate the pharmacological and toxicological effects of two iron-dextran preparations, dextrofer-100 and miofer-100.
- To evaluate their impact on cardiovascular function, neuromuscular activity, and potential protective or adverse reactions in animal models.
Main Methods:
- Intravenous administration of iron-dextran complexes to urethane-anesthetized cats to assess cardiovascular effects.
- Assessment of neuromuscular activity by observing effects resembling curare.
- Evaluation of dextrofer-100's efficacy in preventing anaphylactic shock in guinea pigs and reducing dextran-induced edema in rats.
Main Results:
- Intravenous iron-dextran lowered blood pressure in cats, with miofer-100 showing a stronger effect. Doses of 100 mg Fe3+/kg and higher induced alpha-adrenolytic manifestations.
- Iron-dextran complexes reduced heart contraction amplitudes and exhibited curare-like effects on neuromuscular function.
- Dextrofer-100 protected approximately 70% of guinea pigs from anaphylactic shock and demonstrated anti-edema activity in rats. It also reduced the contractile response of guinea pig ileum to serotonin and histamine.
Conclusions:
- Iron-dextran preparations can induce significant cardiovascular and neuromuscular effects, necessitating careful dosage and administration.
- Dextrofer-100 exhibits potential therapeutic benefits, including anti-anaphylactic and anti-edema properties, warranting further investigation.
- The findings highlight the differential effects of iron-dextran preparations and underscore the importance of comprehensive preclinical evaluation.
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