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S-AMLODIPINE AS A MODERN EFFECTIVE ANTIHYPERTENSIVE AND AN ANTIANGINAL AGENT
Ivan V Chopei1, Ksenia I Chubirko1, Mykhailo V Bychko1
1UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE.
Insights
S-amlodipine effectively treats arterial hypertension and coronary artery disease by improving left ventricular diastolic function. This medication offers clinical benefits and positive hemodynamic changes in patients with preserved systolic function.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Arterial hypertension and coronary artery disease often coexist.
- Preserved left ventricular (LV) systolic function is common in these patients.
- Understanding the effects of specific antihypertensives on diastolic function is crucial.
Purpose of the Study:
- To evaluate the clinical and hemodynamic effects of S-amlodipine.
- To assess S-amlodipine's impact on LV diastolic function in patients with hypertension and coronary artery disease.
- To investigate outcomes in patients with preserved LV systolic function.
Main Methods:
- A study involving 51 patients with arterial hypertension and coronary artery disease.
- Patients were treated with S-amlodipine.
- Clinical and hemodynamic parameters were monitored.
Main Results:
- S-amlodipine demonstrated high clinical effectiveness.
- Treatment led to significant improvement in LV diastolic dysfunction.
- Diastolic function parameters moved closer to normal values.
- Positive hemodynamic changes, including decreased end-diastolic pressure, were observed.
Conclusions:
- S-amlodipine is clinically effective for patients with arterial hypertension and coronary artery disease.
- The drug normalizes left ventricular diastolic function parameters.
- Observed hemodynamic improvements indirectly indicate reduced end-diastolic pressure.
Objective:
The aim: Study of the clinical and hemodynamic effects of S-amlodipine in patients with arterial hypertension associated with coronary artery disease, in individuals with preserved LV systolic function.
Patients And Methods:
Materials and methods: The study includes 51 patients with arterial hypertension associated with coronary artery disease, who were treated with S-amlodipine.
Results:
Results: This study shows the high clinical effectiveness of the use of S-amlodipine in patients with arterial hypertension associated with coronary artery disease. We reveal that treatment of hypertensive patients with coronary artery disease with S-amlodipine leads to improvement of LV diastolic dysfunction, bringing it closer to normal values.
Conclusion:
Conclusions: Clinical effectiveness was associated with positive changes in hemodynamics, and was expressed in the normalization of the left ventricle diastolic function parameters, about which indirectly indicates decreasing of end-diastolic pressure.
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