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Si Miao San relieves hyperuricemia by regulating intestinal flora
1Rehabilitation Center, Hangzhou Wuyunshan Hospital (Hangzhou Institute of Health Promotion), Hangzhou, Zhejiang Province, China.
Biomedical Chromatography : BMC
|December 20, 2023
Summary
Si Miao San (SMS) effectively treats hyperuricemia in rats by reducing uric acid levels and improving kidney health. This traditional herbal formula also positively modulates gut bacteria, offering a novel therapeutic approach.
Area of Science:
- Pharmacology and Traditional Chinese Medicine
- Gastroenterology and Microbiology
Background:
- Hyperuricemia is a metabolic condition characterized by elevated uric acid levels, increasing the risk of gout and kidney disease.
- Intestinal flora dysbiosis is increasingly recognized as a contributing factor to metabolic disorders, including hyperuricemia.
- Si Miao San (SMS) is a traditional Chinese herbal formula with potential therapeutic applications.
Purpose of the Study:
- To investigate the therapeutic effects of Si Miao San (SMS) on hyperuricemia in a rat model.
- To elucidate the underlying mechanisms of SMS action, with a specific focus on its impact on intestinal flora.
- To identify the active components of SMS using high-performance liquid chromatography (HPLC).
Main Methods:
- A rat model of hyperuricemia was established using potassium oxonate.
- Rats were treated with varying concentrations of SMS.
- Evaluations included serum and urine uric acid levels, renal pathology, xanthine oxidase (XO) activity, and intestinal flora analysis via HPLC.
Main Results:
- SMS treatment significantly reduced serum uric acid, blood urea nitrogen, and creatinine levels, while increasing urinary uric acid excretion.
- Renal pathological injuries in hyperuricemic rats were partially alleviated by SMS intervention.
- SMS dose-dependently inhibited XO activity and enhanced intestinal flora diversity, reducing specific bacterial species linked to hyperuricemia.
Conclusions:
- Si Miao San (SMS) demonstrates significant anti-hyperuricemia effects in a rat model.
- SMS may exert its therapeutic benefits by modulating intestinal flora composition and reducing XO activity.
- These findings suggest SMS as a potential therapeutic agent for hyperuricemia, warranting further investigation into its gut microbiome-modulating properties.
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