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Related Experiment Video

Updated: Jul 7, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Enhancing Deep-Seated Melanoma Therapy through Wearable Self-Powered Microneedle Patch.

Chenyuan Wang¹, Guangqin He^1,2, Huanhuan Zhao¹

¹Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.

Advanced Materials (Deerfield Beach, Fla.)

|December 20, 2023

Summary

This study introduces a self-powered microneedle (MN) patch with a flexible triboelectric nanogenerator (F-TENG) for enhanced drug delivery to deep tumors. The integrated system shows superior efficacy in treating deep-seated melanoma in mice.

Keywords:

TENG deep-seated melanoma iontophoresis microneedles transdermal drug delivery

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Area of Science:

Biomedical Engineering
Nanotechnology
Drug Delivery Systems

Background:

Effective treatment of deep-seated tumors requires improved drug penetration via transdermal systems.
Existing microneedle (MNs) and iontophoresis techniques face challenges like skin resistance and power needs, limiting deep tumor treatment.
Wearable, self-powered systems are needed to overcome limitations in transdermal drug delivery for deep-seated tumors.

Purpose of the Study:

To develop a wearable, self-powered microneedle (MN) patch integrated with a flexible triboelectric nanogenerator (F-TENG) for advanced deep-seated tumor therapy.
To enhance transdermal drug delivery efficiency for targeting deep-seated tumors by overcoming skin barrier challenges.

Main Methods:

Fabrication of a wearable, self-powered MN patch incorporating a flexible triboelectric nanogenerator (F-TENG).
Microneedles (MNs) were formulated with water-soluble materials, negatively charged pH-responsive nanoparticles (NPs) loaded with therapeutic drugs.
Evaluation of the integrated MN-patch system in a mouse model with deep-seated melanoma.

Main Results:

The F-TENG harnesses mechanical movements to generate electrical energy, powering the MN patch.
Integrated MN-patch enabled deep skin penetration of therapeutic NPs, with rapid drug release in acidic tumor microenvironments.
A single administration of the integrated MN-patch demonstrated superior therapeutic efficacy in inhibiting deep-located melanoma compared to MN-patch alone.

Conclusions:

The developed wearable, self-powered MN patch with F-TENG offers a promising approach for advanced deep-seated tumor therapy.
This technology effectively enhances transdermal drug delivery to deep tumor sites, overcoming previous limitations.
The system shows significant potential for treating tumors located at deep sites with improved therapeutic outcomes.