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Updated: Jul 7, 2025

A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene
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A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene

Published on: September 16, 2019

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FMR1 Carriers Report Executive Function Changes Prior to Fragile X-Associated Tremor/Ataxia Syndrome: A Longitudinal

David Hessl1,2, Karina Mandujano Rojas1,3, Emilio Ferrer4

  • 1MIND Institute, University of California Davis Health, Sacramento, California, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|December 21, 2023
PubMed
Summary

Executive function decline in men with the FMR1 premutation (PC) precedes and predicts fragile X-associated tremor/ataxia syndrome (FXTAS). These changes in cognitive abilities serve as an early warning sign for the developing movement disorder.

Keywords:
CGG‐repeatFMR1 geneattentionexecutive dysfunctionfragile Xfragile x‐associated tremor/ataxia syndromeinhibitory controlneurodegenerationtrinucleotide repeatworking memory

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