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Related Experiment Video

Updated: Jul 7, 2025

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
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MR Enterography in Ulcerative Colitis: Beyond Endoscopy.

Amir Reza Radmard1, Mehrnam Amouei1, Ala Torabi1

  • 1From the Departments of Radiology (A.R.R., M.A., A.T.) and Pathology (H.S.), Shariati Hospital, Tehran University of Medical Sciences, North Kargar St, Tehran 14117, Iran; Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran (A.R.R., M.A., A.T.); Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran (A.R.S.); Sasan Alborz Biomedical Research Center, Masoud Gastroenterology and Hepatology Center, Tehran, Iran (A.R.S.); Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.G., B.T.); Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY (A.G., B.T.); and Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (A.H.D.).

Radiographics : a Review Publication of the Radiological Society of North America, Inc
|December 21, 2023
PubMed
Summary

Magnetic resonance enterography (MRE) offers valuable insights beyond endoscopy for assessing ulcerative colitis (UC). This advanced imaging technique aids in diagnosing UC activity, chronicity, and complications, complementing endoscopic evaluations.

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Area of Science:

  • Gastroenterology
  • Radiology
  • Medical Imaging

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) affecting the colon and rectum.
  • Crohn disease (CD) is another IBD type, characterized by transmural inflammation anywhere in the GI tract.
  • Endoscopy is the primary tool for UC assessment, while MR enterography (MRE) is underutilized.

Purpose of the Study:

  • To highlight the underused diagnostic potential of MRE in evaluating ulcerative colitis (UC).
  • To demonstrate how MRE provides information beyond endoscopic findings for UC management.
  • To emphasize the role of MRE in differentiating UC from CD and managing complications.

Main Methods:

  • Review of current literature and clinical applications of MR enterography (MRE) for ulcerative colitis (UC).
  • Comparison of MRE findings with endoscopic assessments in UC patients.
  • Discussion of MRE's ability to detect mural, extramural, and extraintestinal abnormalities.

Main Results:

  • MRE provides information on UC activity, disease chronicity, and complications not visible with endoscopy.
  • MRE can identify mural/extramural abnormalities, inaccessible colonic segments, and extraintestinal manifestations.
  • MRE is valuable for excluding undiagnosed Crohn disease (CD) in UC patients and assessing post-colectomy complications.

Conclusions:

  • MRE offers significant advantages over endoscopy in assessing ulcerative colitis (UC), providing comprehensive information.
  • Radiologists can enhance UC management by utilizing MRE to reveal findings beyond endoscopic visualization.
  • MRE is a crucial tool for complex UC cases, including differentiating from CD and managing complications.