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A Novel Anticancer Peptide Derived from Bryopsis plumosa Regulates Proliferation and Invasion in Non-Small Cell Lung

Heabin Kim1, Hyun-Taek Kim2, Seung-Hyun Jung1

  • 1Department of Genetic Resources, National Marine Biodiversity Institute of Korea, Seocheon 33662, Republic of Korea.

Marine Drugs
|December 22, 2023
PubMed

Insights

A novel anticancer peptide (MP06) from green sea algae shows significant anti-cancer effects against non-small-cell lung cancer cells. This peptide effectively inhibits cancer cell proliferation, migration, and metastasis, offering a promising new therapeutic candidate.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Anticancer peptides (ACPs) offer a new generation of targeted cancer therapies.
  • Chemoradiation-resistant lung cancer requires novel therapeutic agents.
  • Green sea algae are a potential source for novel bioactive compounds.

Purpose of the Study:

  • To synthesize and characterize a novel anticancer peptide (MP06) from *Bryopsis plumosa*.
  • To evaluate the anti-proliferative and apoptotic effects of MP06 on non-small-cell lung cancer (NSCLC) cells.
  • To investigate the potential of MP06 in inhibiting cancer cell migration, invasion, and metastasis.

Main Methods:

  • Peptide synthesis and characterization.
  • Cytotoxicity assays and Annexin V/propidium iodide staining for apoptosis.
  • Cellular migration and invasion assays, Western blotting for epithelial-mesenchymal transition markers.
  • Zebrafish embryo xenograft model for metastasis assessment.

Main Results:

  • MP06 demonstrated significantly higher anti-proliferative and apoptotic effects on NSCLC cells compared to non-cancerous lung cells.
  • MP06 suppressed NSCLC cell migration and invasion, inhibiting epithelial-mesenchymal transition markers (N-cadherin, vimentin).
  • MP06 effectively reduced tumor xenograft metastasis in zebrafish embryos.

Conclusions:

  • MP06 is a novel anticancer peptide derived from *Bryopsis plumosa* with potent anti-cancer activity against NSCLC.
  • MP06 exhibits promising therapeutic potential by inhibiting proliferation, migration, invasion, and metastasis.
  • MP06 may function via the ERK signaling pathway, warranting further investigation as a novel drug candidate.
Keywords:
Bryopsis plumoseEMTNSCLCanticancer peptidecancer

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