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Induction of Apoptotic Cell Death in Non-Small-Cell Lung Cancer Cells by MP28 Peptide Derived from Bryopsis plumosa

Heabin Kim1, Seung-Hyun Jung1, Seonmi Jo2

  • 1Department of Bio-Material Research, National Marine Biodiversity Institute of Korea, Seocheon 33662, Republic of Korea.

Marine Drugs
|December 24, 2025
PubMed

Insights

Marine algae yield MP28, a novel anticancer peptide effective against non-small-cell lung cancer cells. MP28 shows selective toxicity, reducing tumor growth in mice with minimal harm to normal cells.

Area of Science:

  • Marine biotechnology
  • Peptide therapeutics
  • Cancer research

Background:

  • Marine algae are rich sources of bioactive peptides.
  • Anticancer peptides offer potential therapeutic strategies.
  • MP28 is a cationic peptide from the green alga *Bryopsis plumosa*.

Purpose of the Study:

  • To characterize the anticancer properties of MP28.
  • To evaluate MP28's efficacy and selectivity against non-small-cell lung cancer (NSCLC).
  • To investigate MP28's mechanism of action and in vivo effects.

Main Methods:

  • Structural modeling of MP28.
  • In vitro assays on NSCLC cell lines (A549, H460, H1299) and normal lung fibroblasts (MRC-5).
  • Flow cytometry analysis and caspase-9 activation assays.
  • In vivo efficacy study using a mouse xenograft model.

Main Results:

  • MP28 exhibits an amphipathic α-helical structure.
  • MP28 selectively reduced viability, clonogenic growth, migration, and invasion of NSCLC cells.
  • MP28 induced apoptosis via the intrinsic pathway and reduced tumor size in vivo.
  • MP28 demonstrated low toxicity toward normal lung fibroblasts.

Conclusions:

  • MP28 is a potent anticancer peptide with selective cytotoxicity against NSCLC.
  • MP28's mechanism involves inducing apoptosis and suppressing tumor progression.
  • MP28 represents a promising candidate for NSCLC therapy with a favorable safety profile.
Keywords:
Bryopsis plumosaEMTanticancer peptideapoptosisnon-small-cell lung cancer

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